New Healing Items
| Item | Description |
| Berry Juice | Heals 20 HP and boosts happiness |
| Fresh Water | Heals 50 HP and boosts happiness |
| Soft Drink | Heals 60 HP and boosts happiness |
| Lemonade | Heals 80 HP and boosts happiness |
| Moo-Moo Milk | Heals 100 HP and boosts happiness |
| Rage Candy Bar | Heals 20 HP and lowers happiness |
| Energy Powder | Heals 50 HP and lowers happiness |
| Energy Root | Heals 200 HP and lowers happiness |
| Heal Powder | Cures all status and lowers happiness |
| Ashes of Life | Restores HP and PP. Cures any status. |
Pokémon Equiptment - Effects takes place when the item is equipped to a pokémon.
| Item | Description | Approximate Location |
| Pink Bow | Boosts Normal-type attacks | Goldentrod City Radio Tower Route 29 on Tuesday |
| Charcoal | Boosts Fire-type attacks | Azalea Town Pokemart A house in Azalea |
| Mystic Water | Boosts Water-type attacks | A guy in a tiny island west of Cherrygrove City |
| Magnet | Boosts Electric-type attacks | Route 37 on Sunday |
| Miracle Seed | Boosts Grass-type attacks | A guy on Route 32 |
| Nevermeltice | Boosts Ice-type attacks | Within the Ice Path |
| Blackbelt | Boosts Fighting-type attacks | North West corner of the Lake of Rage |
| Poison Barb | Boosts Poison-type attacks | Route 32 on Friday Traded Beedrill |
| Soft Sand | Boosts Ground-type attacks | Route 32 |
| Sharp Beak | Boosts Flying-type attacks | Route 40 Traded Doduo, Dodrio, Fearow |
| TwistedSpoon | Boosts Psychic-type attacks | Traded Abra, Kadabra |
| Silver Powder | Boosts Bug-type attacks | Traded Butterfree |
| Hard Rock | Boosts Rock-type attacks | Route 36 on Thursday |
| Spell Tag | Boosts Ghost-type attacks | Blakthorn City on Saturday |
| Dragon Fang | Boosts Dragon-type attacks | Within the Dragon's Den |
| Metal Coat | Boosts Steel-type attacks and evolves 2 other pokémon | S.S. Aqua Traded Magnemite |
| Blackglasses | Boosts Dark-type attacks pokémon | Within Dark Cave |
| Berserk Gene | Doubles the pokémon's attack and is confused. | West of Cerulian City (inside water) |
| Everstone | Prevents evolution. | Professor Elm Second Place Award in the Bug Catching Tournament |
| Focus Band | Lowers the chance of fainting. | Inside the Fighting Dojo in Saffron City |
| Brightpowder | Decreases the enemy's accuracy | Traded Articuno, Zapdos, Moltres |
| Scope Lens | Boosts the chance of scoring a Critical Hit. | Receive it thru the Mystery Gift. |
| Quick Claw | You always attack no matter what. Speed is not a factor anymore. | |
| Exp.Share | Receives EXP even if the pokémon did not battle. | Goldenrond City Trade the Red Scale from Mr. Pokemon. |
| Lucky Egg | Increases the EXP learned. | Traded Chansey |
| Leftovers | Restores a tiny bit of HP after every turn. | Celadon City The large Snorlax east of Vermillion City. |
| Amulet Coin | Doubles money earned from trainer battles. | Goldenrod City Game Corner |
| Smoke Ball | When used, it will always allow you to run. | Goldenrod City ? |
| Cleanse Tag | Like Repel, but it doesn't run out. Reduces the amount of fights with wild Pokémon. | A house on Route 5 |
E-Mail Messages
| Item | Description |
| Flower Mail | Flower design background |
| Surf Mail | Outline of Lapras background |
| Litebluemail | Outline of Dratini background |
| Lovely mail | Hearts with a Outline of Poliwag background |
| PortraitMail | Picture of your Pokémon in the background |
| Music Mail | Outline of Natu background |
| Eon Mail | Outline of Eevee background |
| Bluesky Mail | Outlines of Dragonair and Sentret background |
| Morph Mail | Outline of Ditto background |
| Mirage Mail | Outline of Mew background |