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| Item | Desciption | Location | Price |
| ANTIDOTE | Cures Poison | Pokémart | 100 |
| AWAKENING | Wakes up all sleeping pokémon in battle | Pokémart | 250 |
| BICYCLE | Allows faster movement | Cerulean Bike Shop | 1,000,000 |
| BIKE VOUCHER | Allows you go get a BICYCLE | Vermillion City- Pokémon Fan Club | N/A |
| BURN HEAL | Cures Burns | Pokémart | 250 |
| CALCIUM | Increases Special rating | Celadon Dpt. Store- Floor 5 | 9,800 |
| CARBOS | Increases Speed rating | Celadon Dpt. Store- Floor 5 | 9,800 |
| CARD KEY | Opens locked doors at Silph Co. | Saffron City- Silph Co. | N/A |
| COIN | Cash used at Rocket Game Corner | Cerulean City- Rocket Game Corner | N/A |
| COIN CASE | Holds COINS | Celadon Dpt. Store- Restauran | N/A |
| DIRE HIT | Increases Attack effectiveness | Celadon Dpt. Store- Floor 5 | 650 |
| DOME FOSSIL | Ressurects Kabuto | Mt. Moon | N/A |
| ELIXER | Gives 10 PP to all moves | Random Areas | N/A |
| ESCAPE ROPE | Exits to enterance on the world map | Pokémart & Random Areas | 550 |
| ETHER | Gives 10 PP to one move | Random Areas | N/A |
| EXP. ALL | Shares EXP to all pokémon | Route 15- East of Sarrfon City | 9,800 |
| FIRE STONE | Evolves Fire pokémon | Celadon Dpt. Store- Floor 4 | 2,100 |
| FRESH WATER | Cures thirst, Restores 50 HP | Celadon Dpt. Store- Top Floor | 200 |
| FULL HEAL | Cures any STATUS changes | Pokémart | 600 |
| FULL RESTORE | Cures any STATUS changes and all HP | Pokémart | 3,000 |
| GOLD TEETH | Makes the Warden talk better | Safari Zone | N/A |
| GOOD ROD | Fish for better pokémon besides Magikarp | Fushia City- Fishing Guru | N/A |
| GREAT BALL | Captures pokémon at a rate of 50% | Pokémart | 600 |
| GAURD SPEC. | Protects against Special Attacks | Celadon Dpt. Store- Floor 4 | 700 |
| HELIX FOSSIL | Ressurects Omanyte | Mt. Moon | N/A |
| HP UP | Increases maximum HP a bit | Celadon Dpt. Store- Floor 5, Various Areas | 9,800 |
| HYPER POTION | Restores 200 HP | Pokémart | 1,500 |
| ICE HEAL | Thaws a Frozen pokémon | Pokémart | 250 |
| IRON | Increases Defense rating | Celadon Dpt Store- Floor 4 | 9,800 |
| ITEM FINDER | Detects hidden items within your area | Route 11 Lookout tower- Prof. Oak's Assistant | N/A |
| LEAF STONE | Evloves Grass pokémon | Celadon Dpt. Store- Floor 4 | 2,100 |
| LEMONADE | Cures thirst, Restores 80 HP, trade for TM48 | Celadon Dpt. Store- Top Floor | 350 |
| LIFT KEY | Operates the elevator at Rocket Game Corner basement | Rocket Game Corner basement- Team Rocker Member | N/A |
| MASTER BALL | Captures pokémon at a 100% capture rate | President of Silph Co. | N/A |
| MAX ELIXER | Restores all PP for all moves | Various areas | N/A |
| MAX ETHER | Restores all PP for one move | Various areas | N/A |
| MAX POTION | Restores all HP | Indigo Plateau Pokémart | 2,500 |
| MAX REPEL | Prevents random battles | Pokémart | 700 |
| MAX REVIVE | Revives a fainted pokémon to full health | Various Areas | N/A |
| MOON STONE | Evolves Jigglypuff, Nidorino, Nidorina, and Clefary | Mt. Moon, Cinnabar Island, Route 2, Rock Tunnel | N/A |
| NUGGET | Sell it for 5,000 | Nugget Bridge, Safari Zone, and various areas | N/A |
| OAK'S PARCEL | Prof. Oak's Custom Master Ball from Silph Co. | Veridian City Pokémart | N/A |
| OLD AMBER | Ressurects Aerodactyl | Pewter City- Science Museum | N/A |
| OLD ROD | Used to fish for Magikarp | Vermilion City- Fishing Guru | N/A |
| PARALYZE HEAL | Cures Paralysis | Pokémarts | 200 |
| POKÉ BALL | Captures pokémon at a 25% capture rate | Pokémarts | 200 |
| POKÉ DOLL | If successful, distrcts pokémon and ends battle | Celadon Dpt Store- Floor 4 | 1,000 |
| POKÉ FLUTE | Wakes up sleeping pokémon | Pokémon Tower | N/A |
| POKÉDEX | Used to record data on pokémon | Prof. Oak | N/A |
| POTION | Heals 20 HP | Pokémarts | 300 |
| PP UP | Increases a moves PP | Celadon City, and other various areas | N/A |
| PROTIEN | Increases Attack rating | Celadon Dpt. Store- Floor 5 | 9,800 |
| RARE CANDY | Increases a pokémon's level by 1 | Various areas | N/A |
| REPEL | Prevents random battles for a short while | Pokémarts | 350 |
| REVIVE | Heals a fainted pokémon to half of it's HP | Pokémarts | 1,500 |
| S.S TICKET | Allows you to board the S.S. Anne | Sea Cottage- Bills House | N/A |
| SAFARI BALL | Used to capture pokémon at Safari Zone | Fushia City- Safari Zone | N/A |
| SECRET KEY | Used to gain access to the Cinnibar Island Gym | Pokémon Mansion | N/A |
| SILPH SCOPE | Used to see ghosts at Pokémon Tower | Celadon City- Rocket Game Corner basement | N/A |
| SODA POP | Cures thirst, heals 60 HP, trade for TM49 | Celadon Dpt. Store- Top Floor | 300 |
| SUPER POTION | Heals 50 HP | Pokémarts | 700 |
| SUPER REPEL | Prevents random battles longer than REPEL | Pokémarts | 500 |
| SUPER ROD | Used to fish for the best water pokémon | Route 12- Fishing Guru | N/A |
| THUNDER STONE | Used to evolve Pikachu and Eevee | Celadon Dpt. Store- Floor 4 | 2,100 |
| TOWN MAP | Shows the world map | Pallet Town- Rival's sister | N/A |
| ULTRA BALL | Captures pokémon at a 75% capture rate | Pokémarts | 1,200 |
| WATER STONE | Used to evolve special Water pokémon | Celadon Dpt. Store- Floor 4 | 2,100 |
| X ACCURACY | Used in battle to boost your pokémon's Accuracy temporarily | Celadon Dpt. Store- Floor 5 | 950 |
| X ATTACK | Used in battle to boost your pokémon's Attack temporarily | Celadon Dpt. Store- Floor 5 | 500 |
| X DEFEND | Used in battle to boost your pokémon's Defense temporarily | Celadon Dpt. Store- Floor 5 | 550 |
| X SPECIAL | Used in battle to boost your pokémon's Special temporarily | Celadon Dpt. Store- Floor 5 | 350 |
| X SPEED | Used in battle to boost your pokémon's Speed temporarily | Celadon Dpt. Store- Floor 5 | 350 |